Prof. Dr. Katja Simon, Oxford University, "Autophagy in the Immune system” and Prof. Dr. Quentin Sattentau, Oxford University, “How HIV manipulates macrophages and T cells”

Seminars in Experimental Medicine 12:00
Haus 06, 434
" Autophagy in the renewal, differentiation and homeostasis of immune cells"
Across all branches of the immune system, the process of autophagy is fundamentally important in cellular development, function and homeostasis. Strikingly, this evolutionarily ancient pathway for intracellular recycling has been adapted to enable a high degree of functional complexity and specialization. However, although the requirement for autophagy in normal immune cell function is clear, the mechanisms involved are much less so and encompass control of metabolism, selective degradation of substrates and organelles and participation in cell survival decisions. In this seminar, I will discuss the crucial functions of autophagy in controlling the differentiation and homeostasis of multiple immune cell types.

"HIV dissemination pathways"
Lentiviruses have a long-documented association with macrophages. Abundant evidence exists for in vitro and, in a tissue-specific manner, in vivo infection of macrophages by the primate lentiviruses HIV-1 and SIV. However, macrophage contribution to aspects of HIV-1 and SIV pathogenesis, and their role in viral persistence in individuals on suppressive antiretroviral therapy, remains unclear. In this seminar, I will discuss recent evidence implicating macrophages in HIV-1-mediated disease and the importance of these cells for HIV dissemination.